There is evidence to suggest that synaptic consolidation takes place within minutes to hours of memory encoding or learning, and as such is considered the 'fast' type of consolidation.As soon as six hours after training, memories become impervious to interferences that disrupt synaptic consolidation and the formation of long-term memory.
Molaison lost the ability to encode and consolidate newly learned information leading researchers to conclude the medial temporal lobe (MTL) was an important structure involved in this process.
Specifically, NMDA-receptor antagonists appear to block the induction of both LTP and fear conditioning and that fear conditioning increases amygdaloidal synaptic transmission that would result in LTP.
Synaptic consolidation, when compared to systems consolidation (which is said to take weeks to months to years to be accomplished), is considerably faster.
Distributed learning has been found to enhance memory consolidation, specifically for relational memory.
Experimental results suggest that distributing learning over the course of 24 hours decreases the rate of forgetting compared to massed learning, and enhances relational memory consolidation.