Fluoridating remineralizing of enamel

Undesirable exposure of dentin tubules may result from mechanical abrasion, caries, chemical treatment (e.g., whitening agents), and other factors. 6,521,215 describes compositions comprising a whitening agent comprising 10% peroxide [e.g., urea peroxide (carbamide) or hydrogen peroxide] and a calcium phosphate remineralizing agent. In a fourth embodiment, the present invention is a tooth whitening and remineralizing kit comprising a p H-control composition and a stabilized peroxide composition. The stabilized peroxide composition comprises a soluble peroxide and a calcium orthophosphate solution, wherein the stabilized peroxide composition has an acidic p H.

Plaques are a major cause of both dental decay and inflammatory periodontal disease. In any of the above embodiments, the p H-control composition preferably has a p H from about 8 to about 12 and the stabilized peroxide composition preferably has a p H from about 2 to about 6.

There is also a need in the art for methods that achieve simultaneous whitening and remineralization of teeth in this manner.

5,849,269; 5,820,852; and 5,776,437 describe oral compositions comprising a fluoride ion source, pyrophospate, and calcium peroxide. There is an ongoing need in the art for compositions that whiten teeth and also remineralize them by filling voids associated with tooth decay, mechanical injury, and/or organic stain removal.

The method comprises combining a calcium-containing composition and/or a p H-control composition, as described above, with a second composition comprising a soluble peroxide and a soluble orthophosphate salt, to yield a mixture and simultaneously or sequentially applying the mixture to the teeth.

In a preferred embodiment, the method comprises applying a calcium-containing composition comprising a soluble calcium salt to the teeth and thereafter applying a second composition comprising a soluble peroxide and a soluble orthophosphate salt to the teeth.

These kits advantageously comprise separate compositions comprising a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide, in order to optimize the stability of these components for storage and/or the activity of these components upon use. and at a p H of 7.0, said soluble calcium salt has a calcium ion solubility of at least about 800 ppm, said soluble orthophosphate salt has a phosphate ion solubility of at least about 4000 ppm, and said soluble peroxide has a peroxide solubility of at least about 4000 ppm. A method for whitening and remineralizing teeth, said method comprising the steps of: (a) combining a first composition comprising a soluble calcium salt with a second composition comprising a soluble peroxide and a soluble orthophosphate salt to yield a mixture, and (b) during or after said step (a), applying said mixture to said teeth. The method of claim 30, wherein, in said step (b), said mixture is applied using a tray. The method of claim 30, wherein said mixture is applied, in said step (b), after said combining step (a). The method of claim 30, wherein said second composition has a p H from about 2 to about 6. The method of claim 30, wherein said second composition is obtained by combining a p H-control composition having an alkaline p H and a stabilized peroxide composition comprising said soluble peroxide and said soluble orthophosphate salt, wherein said stabilized peroxide composition has an acidic p H. The method of claim 34, wherein at least one of said p H control composition and said stabilized peroxide composition comprises a soluble calcium salt. The method of claim 34, wherein said first composition is an aqueous solution and both of said p H-control composition and said stabilized peroxide compositions are in a gel form. The method of claim 30, wherein said first composition and said second composition, when combined in an aqueous environment, yield a mixture having a p H from about 5 to about 9. A method for whitening and remineralizing teeth, said method comprising the steps of: (a) applying a first composition comprising a soluble calcium salt to said teeth, and (b) after said step (a), applying a second composition comprising a soluble peroxide and a soluble orthophosphate salt to said teeth. The method of claim 38, wherein, in said step (b), said second composistion is applied using a tray. The method of claim 38, wherein said second composition has a p H from about 2 to about 6. The method of claim 38, wherein said first composition is an aqueous solution and said second composition is in a gel form. The method of claim 38, wherein said second composition is obtained by combining a p H-control composition having an alkaline p H and a stabilized peroxide composition comprising said soluble peroxide and said soluble orthophosphate salt, wherein said stabilized peroxide composition has an acidic p H. The method of claim 42, wherein at least one of said p H control composition and said stabilized peroxide composition comprises a soluble calcium salt. The method of claim 42, wherein said first composition is an aqueous solution and both of said p H-control composition and said stabilized peroxide compositions are in a gel form. The method of claim 38, wherein said first composition and said second composition, when combined in an aqueous environment, yield a mixture having a p H from about 5 to about 9. A tooth whitening and remineralizing composition comprising solid particles of a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide. The composition of claim 46, wherein said composition is in a powder form. The composition of claim 46, wherein said composition is a stable dispersion and further comprises a non-aqueous dispersion medium. The composition of claim 48, further comprising a fluoride ion source. 5,698,182 describes a composition for inhibiting dental calculus and whitening teeth comprising an anticalculus phosphate salt and calcium peroxide. Accordingly, in one embodiment, the present invention is a tooth whitening and remineralizing kit comprising a calcium-containing composition and a stabilized peroxide composition.

The active ingredients may also be separated in a solid composition (e.g., a powder) or in a stable dispersion comprising a non-aqueous dispersion medium. A tooth whitening and remineralization kit comprising: (a) a calcium-containing composition comprising a soluble calcium salt, and (b) a stabilized peroxide composition comprising a soluble peroxide and a soluble orthophosphate salt. The kit of claim 1, wherein said calcium-containing composition further comprises an agent that catalyzes the break down of peroxide, wherein said agent is a catalytic ion. The kit of claim 1, wherein said calcium-containing composition has an alkaline p H. The kit of claim 3, wherein said calcium-containing composition has a p H from about 8 to about 12. The kit of claim 1, wherein said stabilized peroxide composition has an acidic p H. The kit of claim 5, wherein said stabilized peroxide composition has a p H from about 2 to about 6. The kit of claim 5, further comprising: (c) a p H-control composition having an alkaline p H, wherein said calcium-containing composition, said stabilized peroxide composition, and said p H-control composition, when combined in an aqueous environment, yield a mixture having a p H from about 5 to about 9. A tooth whitening and remineralizing kit comprising: (a) a calcium-containing composition comprising a soluble calcium salt, (b) a stabilized peroxide composition comprising a soluble peroxide and having an acidic p H, and (c) a orthophosphate-containing composition comprising a soluble orthophosphate salt, wherein said calcium-containing composition, said stabilized peroxide composition, and said orthophosphate-containing composition, when combined in an aqueous environment, yield a mixture having a p H from about 5 to about 9. A tooth whitening and remineralizing kit comprising: (a) a p H-control composition having an alkaline p H; (b) a stabilized peroxide composition comprising a soluble peroxide and a soluble orthophosphate salt, wherein said stabilized peroxide composition has an acidic p H, wherein at least one of said p H-control composition and said stabilized phosphate composition comprises a soluble calcium salt. A tooth whitening and remineralizing kit comprising: (a) a p H-control composition having an alkaline p H, and (b) a stabilized peroxide composition comprising a soluble peroxide and a calcium orthophosphate solution, wherein said stabilized peroxide composition has an acidic p H. The kit of claim 10, wherein said p H-control composition is in a gel form that is p H-adjusted with a hydroxide compound or a carbonate compound. The kit of claim 10, wherein said stabilized peroxide composition is in a gel form having said calcium orthophosphate dissolved therein. The kit of claim 1, wherein said soluble calcium salt is selected from the group consisting of: (a) calcium sulfate; (b) calcium chloride; (c) calcium nitrate; (d) calcium acetate; (e) calcium lactate; and (f) combinations thereof. The kit of claim 1, wherein said soluble orthophosphate salt is selected from the group consisting of: (a) a peroxyorthophosphate; (b) monosodium phosphate; (c) disodium phosphate; (d) trisodium phosphate; (e) monopotassium phosphate; (f) dipotassium phosphate; (g) tripotassium phosphate; (h) monoammonium phosphate; (i) diammonium phosphate; (j) triammonium phosphate; (k) monocalcium phosphate monohydrate (MCMP); (l) monocalcium phosphate anhydrate (MCPA); and (m) combinations thereof. The kit of claim 14, wherein said peroxyphosphate is selected from the group consisting of: (a) a peroxymonophosphate; (b) a diperoxymonophosphate; and (c) combinations thereof. The kit of claim 15, wherein said peroxymonophosphate is selected from the group consisting of: (a) monopotassium peroxymonophosphate; (b) dipotassium peroxymonophosphate; (c) tripotassium peroxymonophosphate; (d) monosodium peroxymonophosphate; (e) disodium peroxymonophosphate; (f) trisodium peroxymonophosphate; (g) monoammonium peroxymonophosphate; (h) diammonium peroxymonophosphate; (i) triammonium peroxymonophosphate; and (j) combinations thereof. The kit of claim 15, wherein said diperoxymonophosphate is selected from the group consisting of: (a) monopotassium diperoxymonophosphate; (b) dipotassium diperoxymonophosphate; (c) tripotassium diperoxymonophosphate; (d) monosodium diperoxymonophosphate; (e) disodium diperoxymonophosphate; (f) trisodium diperoxymonophosphate; (g) monoammonium diperoxymonophosphate; (h) diammonium diperoxymonophosphate; (i) triammonium diperoxymonophosphate; and (j) combinations thereof. The kit of claim 1, wherein said soluble peroxide is selected from the group consisting of: (a) hydrogen peroxide; (b) urea peroxide (carbamide); (c) a peroxyphosphate; (d) orthophosphate peroxyhydrate; (e) pyrophosphate peroxyhydrate; (f) triphosphate peroxyhydrate; (g) metaphosphate peroxyhydrate; (h) peroxyborate; (i) peroxycarbonate; (j) peroxysilicate; and (k) combinations thereof. The kit of claim 18, wherein said peroxyphosphate is selected from the group consisting of: (a) a peroxymonophosphate; (b) a peroxydiphosphate; (c) a diperoxymonophosphate; and (d) combinations thereof. The kit of claim 19, wherein said peroxymonophosphate is selected from the group consisting of: (a) monopotassium peroxymonophosphate; (b) dipotassium peroxymonophosphate; (c) tripotassium peroxymonophosphate; (d) monosodium peroxymonophosphate; (e) disodium peroxymonophosphate; (f) trisodium peroxymonophosphate; (g) monoammonium peroxymonophosphate; (h) diammonium peroxymonophosphate; (i) triammonium peroxymonophosphate; and (j) combinations thereof. The kit of claim 19, wherein said peroxydiphosphate is selected from the group consisting of: (a) monopotassium peroxydiphosphate; (b) dipotassium peroxydiphosphate; (c) tripotassium peroxydiphosphate; (d) tetrapotassium peroxydiphosphate; (e) monosodium peroxydiphosphate; (f) disodium peroxydiphosphate; (g) trisodium peroxydiphosphate; (h) tetrasodium peroxydiphosphate; (i) monoammonium peroxydiphosphate; (j) diammonium peroxydiphosphate; (k) triammonium peroxydiphosphate; (l) tetraammonium peroxydiphosphate; and (m) combinations thereof. The kit of claim 19, wherein said diperoxymonophosphate is selected from the group consisting of: (a) monopotassium diperoxymonophosphate; (b) dipotassium diperoxymonophosphate; (c) tripotassium diperoxymonophosphate; (d) monosodium diperoxymonophosphate; (e) disodium diperoxymonophosphate; (f) trisodium diperoxymonophosphate; (g) monoammonium diperoxymonophosphate; (h) diammonium diperoxymonophosphate; (i) triammonium diperoxymonophosphate; and (j) combinations thereof. The kit of claim 18, wherein said orthophosphate peroxyhydrate is selected from the group consisting of: (a) sodium orthophosphate peroxyhydrate; (b) potassium orthophosphate peroxyhydrate; (c) ammonium orthophosphate peroxyhydrate; and (d) combinations thereof. The kit of claim 18, wherein said pyrophosphate peroxyhydrate is selected from the group consisting of: (a) sodium pyrophosphate peroxyhydrate; (b) potassium pyrophosphate peroxyhydrate; (c) ammonium pyrophosphate peroxyhydrate; and (d) combinations thereof. The kit of claim 18, wherein said triphosphate peroxyhydrate is selected from the group consisting of: (a) sodium triphosphate peroxyhydrate; (b) potassium triphosphate peroxyhydrate; (c) ammonium triphosphate peroxyhydrate; and (d) combinations thereof. The kit of claim 18, wherein said metaphosphate peroxyhydrate is selected from the group consisting of: (a) sodium metaphosphate peroxyhydrate; (b) potassium metaphosphate peroxyhydrate; (c) ammonium metaphosphate peroxyhydrate; and (d) combinations thereof. The kit of claim 1, wherein said stabilized peroxide composition further comprises a fluoride ion source. The kit of claim 27, wherein said fluoride ion source is selected from the group consisting of: (a) sodium fluoride; (b) potassium fluoride; (c) sodium monofluorophosphate; (d) sodium hexafluorosilicate; and (e) combinations thereof. The present invention relates to compositions and methods for whitening, mineralizing, and/or fluoridating teeth. Also included in the composition is calcined alumina. The calcium-containing composition comprises a soluble calcium salt.

They use sugars and other fermentable carbohydrates to produce acids, which cause demineralization of the tooth surface, and polymers, which bind the organisms themselves to the tooth surface. Unfortunately, the bleaching process for removing stains can simultaneously reduce the microhardness of enamel and dentin, cause post-treatment tooth sensitivity, and/or increase tooth susceptibility to demineralization. 6,290,935 describes an oral composition comprising a peroxide first component (e.g., hydrogen peroxide, peroxydiphosphate, urea peroxide (carbamide), metal peroxides such as calcium peroxide, and salts of perborate, persilicate, perphosphate, and percarbonate) and a silicate clay activator second component, implanted with Fe ions. Also, to any of the above-mentioned compositions, excluding the stabilized peroxide composition, metal ions (e.g., Mn, etc.) or other agents may be added in order to catalyze the break down of peroxide when contacted with (e.g., by mixing) the stabilized peroxide composition at or near the time of use. As an alternative means of separating a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide prior to use, these components may be provided in a tooth whitening and remineralizing composition comprising solid particles, such as a powder composition. In particular, without being bound by theory, it has now been determined that (i) peroxide in solution may be stabilized in the presence of orthophosphate ion and/or in a composition at acidic p H, (ii) conversely, in order for peroxide to become activated for tooth whitening upon use, it may be destabilized by removing the soluble orthophosphate ion and/or increasing p H, and (iii) calcium orthophosphate solutions at high concentrations suitable for tooth remineralization may be stabilized at acidic p H and precipitated onto the tooth surface by increasing p H.On the crown end of the tooth, the dentin tubule ends are normally sealed by the enamel. 6,102,050 and 5,967,155 describe dental flosses that administer various compounds to interproximal and subgingival dental areas for purposes such as whitening, demineralization, and desensitization. The stabilized peroxide composition comprises a soluble peroxide and has an acidic p H.These dentin tubules pass all the way through the dentin from the enamel-sealed crown end to the pulp chamber. 6,221,341 describes compositions for whitening teeth and/or having antimicrobial activity. In addition to titanium dioxide as a whitening agent, other ingredients that may be incorporated into the floss include desensitizing agents, fluorides, peroxide compounds, and calcium abrading agents. The orthophosphate-containing composition comprises a soluble orthophosphate salt, wherein the three compositions, when combined in an aqueous environment, yield a mixture having a p H from about 5 to about 9.

Search for fluoridating remineralizing of enamel:

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Without being bound by theory, it is believed that the porous nature of the enamel layer permits staining agents and discoloring substances to permeate into the enamel and discolor a tooth. 5,902,568 describes compositions comprising hydrogen peroxide or a precursor and bicarbonate salt components that are maintained separate from one another to prevent their reaction prior to use. In a second embodiment, the present invention is a tooth whitening and remineralizing kit comprising a calcium-containing composition, a stabilized peroxide composition, and an orthophosphate-containing composition.

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